esophageal cancer
Conditions
Interventions
GroupT:Individualized positive end-expiratory pressure titrated by driving pressure was used during surgery in the lateral position and a fixed 5cmH2O positive end-expiratory pressure was used during
GroupL:Individualized positive end-expiratory pressure titrated by driving pressure was used during surgery in the supine position and a fixed 5cmH2O positive end-expiratory pressure was used during s
GroupI:Individualized positive end-expiratory pressure was used throughout the procedure
GroupP:A fixed positive end-expiratory pressure of 5cmH2O was used throughout the procedure
Sponsors
The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age 18-75 years old;2.Body Mass Index(BMI)=18.5~25kg/m^2;3.American society of anesthesiologists(ASA) Grades ?~?;4.The time of one-lung ventilation>1h;5.With the approval of the hospital ethics committee, they agree to sign a written consent to participate in the study;
Exclusion criteria
Exclusion criteria: 1.patients with severe cardiovascular disease or severe hepatic and renal insufficiency; 2.Previous severe complications history including pulmonary infection, pleural effusion, atelectasis, respiratory failure, and cardiogenic pulmonary edema;3.The contraindications of the application of positive end expiratory pressure(tension pneumothorax, pulmonary bullae, severe barotrauma, hypovolemic shock, bronchopleural fistula, high intracranial pressure);4.hemorrhea(>500ml);5.hemodynamic instability
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Partial pressure of oxygen;Oxygenation index; | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative pulmonary complications;driving pressure;compliance;airway resistance;Tidal volume;Peak airway pressure;Plateau pressure;Positive end-expiratory pressure;Ph value;Carbon dioxide partial pressure;Alveolar void space;The situation of reintubation;Oxygen saturation on the first postoperative day;Length of stay; | — |
Countries
China
Contacts
Public ContactHailin Liu
The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University
Outcome results
None listed