The state of elderly patients receiving anesthesia during joint replacement surgery
Conditions
Interventions
Test group:Anesthesia induction protocol: remifentanil tosylate 0.15-0.3mg/kg+sufentanil 0.3-0.5 µ g/kg+rocuronium bromide 0.6mg/kg
Anesthesia maintenance plan: Inhalation of sevoflurane 1%+remifentan
control group:Anesthesia induction protocol: intravenous injection of propofol 1.0-2.5 mg/kg+sufentanil 0.3-0.5 µ g/kg+rocuronium bromide 0.6mg/kg
Anesthesia maintenance plan: inhalation of sevofluran
Sponsors
The First Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 74 Years
Inclusion criteria
Inclusion criteria: (1) Age>=60 years and =18.5 kg/m² and <28 kg/m²; (5) Sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Severe heart, brain, liver and kidney diseases; (2) Psychiatric diseases (including but not limited to schizophrenia, mania, etc.) or long-term use of psychotropic drugs; (3) Allergy or contraindication to benzodiazepines, propofol, opioids or muscle relaxants; (4) Modified Mahalanobis score of IV; (5) Participated in other drug clinical trials in the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean arterial pressure (MAP);Heart rate (HR);Respiratory rate (RR);bispectral index(BIS value); | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient awakening time and duration of stay in PACU;Preoperative and postoperative cognitive function assessment of patients ;Adverse event occurrence and use of vasoactive drugs;Total length of hospital stay; | — |
Countries
China
Contacts
Public ContactYangJuan
The First Affiliated Hospital of Kunming Medical University
Outcome results
None listed