Postoperative cognitive dysfunction
Conditions
Interventions
hydrogen rich group:orally receive hydrogen-rich water (200 mL, with a hydrogen concentration of 1.6 ppm), every 12 hours for a duration of 7 days, commencing on the day prior to the surgical procedur
celecoxib group: orally receive either celecoxib (0.2 g),every 12 hours for a duration of 7 days, commencing on the day prior to the surgical procedure.
control group:normal saline 200ml, every 12 hours for a duration of 7 days, commencing on the day prior to the surgical procedure.
Sponsors
The Second Affiliated Hospital of Shandong First Medical University
Eligibility
Sex/Gender
All
Age
70 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) age over 70 years old;(2) femoral neck fracture; (3) Unilateral hip replacement was performed in all patients. (4) A simple mental state score greater than 17 points (5) American Society of Anesthesiology (ASA) grade I to II; (6) no infectious disease; (7) The patient or family members jointly sign the consent form.
Exclusion criteria
Exclusion criteria: (1) cerebrovascular history; (2) Communication barriers; (3) Severe organic lesions of liver and kidney function (4) local ulceration of infection with previous history of infection. Diagnostic criteria for POCD: MMSE score less than 17 points, or >=3 points decrease from baseline value. MMSE score: The highest score is 30, with scores >=25 indicating normal cognitive function, 19-24 mild abnormalities, 10-18 moderate abnormalities, and <9 severe cognitive impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the occurrence of POCD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain assessment;interleukin-6 (IL-6);C-reactive protein (CRP) ; | — |
Countries
China
Contacts
Public ContactChen Yinzhong
The Second Affiliated Hospital of Shandong First Medical University
Outcome results
None listed