Difficult-to-treat bacterial infections
Conditions
Interventions
Sponsors
Shanghai Public Health Clinical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with multidrug-resistant bacterial infection (based on the drug susceptibility testing in our hospital or other 3A hospitals); 2. The pathogen that the patient is infected with should meet one of the following conditions: 1) The pathogenic bacteria resistants to all existing antibiotics; 2) Pathogenic bacteria are resistant to key antibiotics (see WHO 2017's 12 class super bacteria); 3) The pathogenic bacteria is only sensitives to key antibiotics in vitro, but the antibiotic treatment is ineffective (ineffective is defined as repeated infection of the target bacteria for two months, meanwhile, using the antibiotic treatment can not Clear the pathogen); 4) Pathogens have limited use of critical sensitive antibiotics (in patients with organ dysfunction or allergic reactions to this antibiotic); 3. At least one phage can be screened to lyse the pathogenic bacteria; 4. The phages can be administrated through spraying, external application, atomization inhalation, perfusion, local injection or diversion tube; 5. The patient and his/her guardian are fully read, understand and sign the informed consent statement.
Exclusion criteria
Exclusion criteria: 1. The infection can be effectively controlled by antibiotic treatment; 2. The phage can be only administrated via intravenous administration; 3. The patient is not suitable to involved in this study, determined by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bacterial culture and identification results; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Outcomes; | — |
Countries
China
Contacts
Public ContactBao Juan
Shanghai Public Health Clinical Center
Outcome results
None listed