Type A aortic dissection
Conditions
Interventions
Cyclopofol group:1) Anesthesia induction: intravenous injection of cyclopofol in the cyclopofol group
2) Anesthesia maintenance: Cyclopofol, sufentanil (1 ug/kg/h) and rocuronium (0.6 mg/kg/h) were co
Propofol group:1) Anesthesia induction: Propofol group intravenously injected propofol
2) Anesthesia maintenance: The propofol group was continuously infused with propofol at a rate of 2.0-3.0 mg/kg/h
Sponsors
Beijing Anzhen Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Age between 18 and 70 years, regardless of sex; 2.Diagnosed with acute Stanford type A aortic dissection; 3.Scheduled to undergo total aortic arch replacement surgery under cardiopulmonary bypass (CPB); 4.Body Mass Index (BMI) between 18.5 and 35 kg/m^2; 5.American Society of Anesthesiologists (ASA) physical status classification of III to IV; 6.Patients with adequate comprehension, able to understand the purpose of the study, and voluntarily sign the informed consent form; 7.Patients who have undergone thorough preoperative clinical evaluation and are considered eligible for surgery, without severe comorbidities, and are able to tolerate anesthesia and the surgical procedure.
Exclusion criteria
Exclusion criteria: 1.Sudden vascular rupture occurring after enrollment but before surgery; 2.Patients with unstable vital signs preoperatively requiring pharmacologic or mechanical support; 3.Patients with preexisting persistent arrhythmias that significantly affect hemodynamics (e.g., atrial fibrillation, atrial flutter, ventricular tachycardia, third-degree atrioventricular block, sick sinus syndrome) or those with implanted pacemakers/ICDs; 4.Patients with a history of coronary artery disease or chronic heart failure; 5.Known allergy to propofol or ciprofol; 6.Presence of other significant organ diseases (e.g., hepatic, renal, respiratory, hematologic, neurologic, immunologic, or metabolic disorders); 7.Pregnant patients; 8.History of malignant hyperthermia; 9.Recent (within 3 months) history of alcohol or substance abuse; 10.Prolonged QT interval (>=450 ms for males, >=460 ms for females); 11.Known central nervous system disorders (e.g., stroke, epilepsy); 12.Severe psychiatric disorders; 13.Any other condition deemed by the investigator to potentially interfere with the study results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coefficient of variation of mean arterial pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure; | — |
Countries
China
Contacts
Public ContactSheng Wang
Beijing Anzhen Hospital
Outcome results
None listed