Colorectal tumor
Conditions
Interventions
Control group(C group):Administer an equal volume of normal saline at the same time during anesthesia induction and maintenance
Esketamine group (K group):The application of esketamine during the perioperative period
Sponsors
People's Hospital of Leshan
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Elderly patients >=65 years of age, regardless of gender; 2.ASA physical condition class I-III; 3.Elective laparoscopic abdominal surgery with general anesthesia and intubation, expected to be extubated, and with a surgical duration of >=2 hours; 4.The subject or their family member signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Those who refuse to participate in the research and those who are unable to communicate due to aphasia, severe hearing impairment, or other difficulties; 2.Patients with diagnosed mental illnesses, such as schizophrenia, depression, and dementia; 3.Patients with a history of chronic pain or a history of substance abuse, including alcohol, opioids, or other psychotropic medications; 4.Those who have allergic reactions to any of the medications used in the study; 5.There is one contraindication for the use of esketamine injection: (1) High intraocular pressure (glaucoma) or penetrating ocular trauma; (2) Increased intracranial pressure; (3) Poorly controlled or untreated hypertension (systolic/diastolic blood pressure at rest: 180/100 mmHg); (4) Untreated or inadequately treated hyperthyroidism; 6.Critical illnesses: (1) Unstable angina pectoris or myocardial infarction occurred within 6 months. (2) Acute lung injury or acute respiratory distress syndrome within 3 months; respiratory failure, severe chronic obstructive pulmonary disease (GOLD grade III-IV). (3) Severe liver dysfunction (Child-Pugh grade C). (4) Glomerular filtration rate < 30 ml/min. (5) Heart failure (NYHA cardiac function grade III-IV); 7.Those who have already participated in clinical studies of other drugs or medical devices;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of recovery scores (QoR-15); | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of recovery scores (QoR-15);Opioid consumption;The time for intestinal function recovery(The time from tracheal extubation to the first passage of flatus);Adverse reactions (moderate to severe nausea and vomiting, restlessness, delirium, hallucination, nightmare, diplopia, dizziness);The 30-day all - cause mortality rate after surgery;The number of postoperative hospital stay days (the number of days from the day of surgery to the day of discharge);Score of the Hospital Anxiety and Depression Scale;Numeric rating scales;Sleep quality; | — |
Countries
China
Contacts
Public ContactSong Lai
People's Hospital of Leshan
Outcome results
None listed