Postoperative sleep disturbance,POSD
Conditions
Interventions
Esketamine group:Esketamine 0.3mg/kg/h was pumped continuously during the operation.
Dexmedetomidine group:During the operation, dexmedetomidine was injected continuously with 0.4ug /kg/h.
Esketamine combined with dexmedetomidine group:Intraoperatively, dexmedetomidine 0.4ug /kg/h and esketamine 0.3mg/kg/h were continuously pumped.
Normal saline group:Give equal volume normal saline.
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Women undergoing gynecological laparoscopy surgery under elective general anesthesia; 2. Age 18-65 years old; 3.ASA grade I - III; 4.BMI 18-30 kg/m^2; 5. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Preoperative sleep disorder, AIS > 6 or PSQI>=10; 2.Preoperative heart rate less than 55 beats per minute or the presence of atrioventricular block; 3.Acute cerebral hemorrhage or stroke; 4.Long-term use of psychotropic drugs; 5.Obstructive sleep apnea syndrome; 6.Chronic obstructive pulmonary disease; 7.Severe liver and kidney dysfunction; 8.A history of surgery within the last 3 months; 9.BMI >30 kg/m^2; 10.Allergy to the drugs involved in this study; 11.Patients with contraindications to the use of esketamine or dexmedetomidine; 12.Has been involved in other clinical studies; 13.Unable to understand the content of the relevant scale
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of sleep disorders in the first three nights after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxiety and depression score;Postoperation pain;Postoperative recovery quality;Postoperative adverse events;The first time of the postoperative exhaust;Postoperative nausea and vomiting score; | — |
Countries
China
Contacts
Public ContactChen Xiuxia
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed