Liver transplantation ischemia-reperfusion injury in children with biliary atresia
Conditions
Interventions
Deflurane group:None
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Infant liver transplant recipients; 2.No history of using immunosuppressants or hormones within 1 year; 3. First surgery; 4. Pediatric end-stage liver disease scoring system (PELD)<20;
Exclusion criteria
Exclusion criteria: 1.preoperative renal dysfunction; 2.complicated with serious cardiopulmonary or endocrine diseases; 3.Congenital vascular malformations affect the procedure; 4.Different postoperative immunosuppression regimens; 5.No follow-up conditions;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative acute kidney injury; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cytokine;RNA-seq analyze;Oxidative stress index;GST-a levels;Postoperative liver function changes;Survival rate and occurrence of complications within 1 year (1 month, 3 months, 6 months, 12 months follow-up) after surgery;Urinary protein; | — |
Countries
China
Contacts
Public ContactLiu Wei
Children's Hospital of Chongqing Medical University
Outcome results
None listed