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Single-Center, Prospective, Observational Study on the Efficacy and Safety of Probiotics Combined with Berberine Hydrochloride in IBS Patients with Small Intestinal Bacterial Overgrowth (SIBO)

Single-Center, Prospective, Observational Study on the Efficacy and Safety of Probiotics Combined with Berberine Hydrochloride in IBS Patients with Small Intestinal Bacterial Overgrowth (SIBO)

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500102654
Enrollment
Unknown
Registered
2025-05-18
Start date
2025-06-01
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irritable Bowel Syndrome with Small Intestinal Bacterial Overgrowth (IBS-SIBO)

Interventions

Patients with IBS (constipation):None
Patients with IBS (diarrhoea):None
IBS patients (mixed):None

Sponsors

Affiliated Hospital of Xuzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Age between 18-80 years old; 2. Patients who meet the inclusion criteria for IBS and voluntarily participate in clinical studies.

Exclusion criteria

Exclusion criteria: 1. Non gastrointestinal disease patients; 2. Severe major organ comorbidities (heart, lungs, liver, kidneys, etc.); 3. Patients with a history of major gastrointestinal surgery; 4. Currently pregnant.

Design outcomes

Primary

MeasureTime frame
Bacterial overgrowth in the small intestine turns negative;—

Secondary

MeasureTime frame
Relief of abdominal symptoms;Anxiety and depression improve;Sleep Improvement;—

Countries

China

Contacts

Public ContactPang Xunlei

Affiliated Hospital of Xuzhou Medical University

pangxunlei2024@163.com+86 136 4520 7660

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026