Perioperative Neurocognitive Disorders
Conditions
Interventions
Experimental group:Dexmedetomidine hydrochloride nasal spray 100µg, administered nasally 30 minutes before surgery.
Control group:Midazolam 2-3mg, morphine 0.1mg/Kg, intramuscular injection 30 minutes before surgery
Sponsors
The Second Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients aged >=18 years; 2. The American Society of Anesthesiologists (ASA) score was grade II-IV; 3. Patients undergoing elective off-pump coronary artery bypass grafting; 4.Left ventricular ejection fraction >=40%
Exclusion criteria
Exclusion criteria: 1. Refusal to participate in this study; 2. Inconsistent surgical type; 3. Emergency surgery; 4. Hepatic or renal insufficiency (Child-Pugh grade C, preoperative renal replacement therapy); 5. History of drug or alcohol abuse; 6. History of general anesthesia drug allergy; 7. Severe preoperative dementia; 8. Language barrier preventing communication; 9. Mental illness rendering cooperation impossible; 10. Patients with a history of prior traumatic brain injury or neurosurgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Level of sedation;Postoperative delirium;Postoperative cognitive dysfunction;Blood Pressure ;Heart Rate;Pulse oxygen saturation ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative dosage of vasoactive drugs;Intraoperative dosage of opioid anesthetics;Postoperative time in ICU;Postoperative time of mechanical ventilation ;Postoperative complications within 30 days ;Postoperative mortality rate ; | — |
Countries
China
Contacts
Public ContactGao Jingui
The Second Hospital of Hebei Medical University
Outcome results
None listed