Intestinal health
Conditions
Interventions
Control group: intestinal barrier non-aging group (Part I):None
Case Group: Intestinal Barrier Aging Group (Part I):None
Bifidobacterium bifidum probiotic group (Part II: Interventional study):1g of Bifidobacterium bifidum (1×10^10 CFU) of healthy infant origin was administered 1 hour after lunch daily for 3 months duri
Biostime (Part II: Interventional Study):During the intervention period, Bifidobacterium bifidum 1×10^10 CFU 2'-FL food grade (90%) 1g (the two components are integrated into 1g of the test substance)
Placebo group (Part II: Interventional study):1g of maltodextrin was administered 1 hour after lunch daily for 3 months during the intervention period.
Human milk oligosaccharide prebiotic group (Part II: Interventional study):During the intervention period, 1g of 2'-FL food grade (90%) was administered 1 hour after lunch every day for 3 months.
Sponsors
Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University
Eligibility
Sex/Gender
All
Age
55 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age range of 55-65 years old (including both ends); 2. Able to take care of oneself in daily life; 3. Have lived locally for three years or more; 4. I and my family members cooperate, voluntarily participate, and sign an informed consent form. Inclusion criteria for the aging group of intestinal tract: any one or more of the three indicators of plasma diamine oxidase (DAO), D-lactate (D-LC), and bacterial endotoxin (BT) show an upward trend and exceed the standard value range; Inclusion criteria for the non aging group of intestinal barrier: plasma diamine oxidase (DAO), D-lactate (D-LC), and bacterial endotoxin (BT) did not show an upward trend and did not exceed the standard value range.
Exclusion criteria
Exclusion criteria: 1. Suffering from severe organic lesions (such as severe liver disease with cirrhosis, severe renal insufficiency, severe COPD, severe cardiovascular disease, etc.); 2. Diagnosed with malignant tumors within the past two years; 3. Received antibiotic treatment within the past month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut Microbiota;Plasma diamine oxidase;D-LC;Bacterial endotoxins;Short-chain fatty acids;Serum lipopolysaccharide binding protein;Zounulin;I-FABP;Tight junction proteins; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-1ß;IL-6;IL-10;TNF-a;C-reactive protein;Immune cells;ß-galactosidase;Blood routine;Liver function and renal function;Fasting blood glucose;Fasting lipids;Glycosylated hemoglobin; | — |
Countries
China
Contacts
Public ContactXi Shen
Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University
Outcome results
None listed