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Study on the Efficacy and Safety of Inhaled Nitric Oxide Combined with Prone Position Ventilation Following Surgery for Acute Type A Aortic Dissection

Study on the Efficacy and Safety of Inhaled Nitric Oxide Combined with Prone Position Ventilation Following Surgery for Acute Type A Aortic Dissection

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500102646
Enrollment
Unknown
Registered
2025-05-18
Start date
2025-05-18
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic dissection

Interventions

Supine ventilation treatment group:None
Supine ventilation combined with iNO treatment group:None

Sponsors

The Second Affiliated Hospital, Zhejiang University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. CT angiography indicates Stanford type A aortic dissection; 2. Patients who meet the surgical standards and receive surgical treatment in our hospital; 3. Postoperative persistent hypoxemia patients are defined as those whose blood gas examination shows a ratio of oxygen arterial partial pressure (PaO2) to inhaled oxygen fraction (FiO2) equal to or less than 150 mmHg (PaO2/FiO2<=150) for more than 2 hours, ruling out cardiogenic pulmonary edema.

Exclusion criteria

Exclusion criteria: 1.Patients who die within 24 hours after surgery; 2. Patients with severe postoperative complications, such as severe multiple organ failure

Design outcomes

Primary

MeasureTime frame
Blood gas results at various time points;

Secondary

MeasureTime frame
Blood test results;Ventilator mechanics ;Hemodynamics;Imaging findings;

Countries

China

Contacts

Public ContactGensheng Zhang

The Second Affiliated Hospital, Zhejiang University School of Medicine

genshengzhang@zju.edu.cn+86 188 0681 2331

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026