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Oligodendrocyte Prosaposin Restores Subarachnoid Hemorrhage-Induced Consciousness Impairment

Effect of damage to the CL-mPFC circuit in the thalamus caused by white matter injury after subarachnoid hemorrhage on the sleep-wake cycle

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500102636
Enrollment
Unknown
Registered
2025-05-16
Start date
2019-05-04
Completion date
Unknown
Last updated
2025-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

subarachnoid hemorrhage

Interventions

The subarachnoid hemorrhage group(Plasma and brain tissue):None
control group (plasma):None
brain tumor control group(Peritumoral brain tissue):None

Sponsors

The First Affiliated Hospital of Soochow University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Patients diagnosed with spontaneous subarachnoid hemorrhage (confirmed by DSA); 2.Between the ages of 18 and 75; 3.Surgery performed within 24 hours of onset; 4.Patients who agree to participate in the study and sign the informed consent form;

Exclusion criteria

Exclusion criteria: 1.Patients with severe liver or kidney dysfunction; 2.Patients with a history of hemorrhagic cerebrovascular disease or central nervous system diseases; 3.Pregnant or breastfeeding women; 4.Patients with a history of severe trauma or surgery within the past month; 5.Patients taking anticoagulant drugs (such as warfarin, heparin, etc.) or antiplatelet drugs (such as aspirin, clopidogrel, etc.); 6.Patients with a history of acute or chronic infection, immune system diseases, or malignant tumors;

Design outcomes

Primary

MeasureTime frame
The levels of Psap protein in oligodendrocytes significantly decreased in the brain after subarachnoid hemorrhage (SAH).;

Countries

China

Contacts

Public ContactHaiying Li

The First Affiliated Hospital of Soochow University

lhy1015@suda.edu.cn+86 512 67507192

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026