None
Conditions
Interventions
Ciprofol Group:A loading dose of 0.1 mg/kg of intravenous bolus injection was injected at a constant rate,followed by a pump of ciprofol at a starting rate of 0.3 mg/kg/h.
Propofol group:A loading dose of propofol injection was given at a constant intravenous bolus rate of 0.5 mg/kg, followed by a pump of propofol at a starting rate of 1.5 mg/kg/h.
Sponsors
Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Gender is not limited, age 18>= and = 18 and = 60 and = 90 mmHg and = 60 mmHg and = 92%;
Exclusion criteria
Exclusion criteria: (1) Patients with contraindications to regional anesthesia, such as coagulation dysfunction; (2) Patients with a history of cardiovascular system, respiratory system, nervous system, gastrointestinal tract or a history of alcoholism and drug abuse three months before surgery; (3) Those who are allergic to propofol injection, excipients in cyclopofol injection and various anesthetic drugs; (4) Patients who use any drugs for hypnosis, anesthesia, analgesia, and muscle relaxant before surgery; (5) Patients with mental illness or inability to cooperate; (6) Patients who are judged to be unsuitable for inclusion for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage of time to maintain MOAA/S 3-4 points, MOAA/S 1-2 points, and MOAA/S=5 points to the entire study dosing time;;The time from initiation of intravenous bolus loading dose to the first MOAA/S<4, and the proportion of subjects with MOAA/S<4 within 3 minutes;Proportion of subjects receiving salvage sedation;Patient's vital signs;The number of dose adjustments that occurred;Sedative medication use;The time from stopping the infusion of the investigational drug to reaching MOAA/S=5 points for the first time after surgery;Duration of stay in the recovery room;Recovery when leaving the room; | — |
Countries
China
Contacts
Public ContactChen Mi
Affiliated Hospital of Guizhou Medical University
Outcome results
None listed