stroke
Conditions
Interventions
Combined intervention group:rTMS,taVNS
rTMS group:rTMS, Sham taVNS
taVNS group:taVNS, Sham rTMS
Control group:Sham rTMS and taVNS
Sponsors
The Second Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Right-handed patients with first-onset stroke who meet the diagnostic criteria for stroke; 2. Unilateral lesions confirmed by CT or MRI as hemorrhagic or ischemic lesions in the basal ganglia region; 3. Disease course of 15 days to 2 months, regardless of gender, aged 40 to 80 years;4.Clear consciousness and stable vital signs; 5.Upper limb dysfunction, Brunnstrom stage II to IV and upper limb Fugl-Meyer score <43 points;6.No mental abnormalities; 7.Agree to the rehabilitation program and be able to cooperate with treatment guidance;8.Patients and/or family members understand and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with severe cognitive impairment or mental illness who cannot cooperate with treatment and evaluation; 2.Metal foreign bodies in the brain;3.History of epilepsy or family history of epilepsy;4. Patients with pacemakers, stents, or cochlear implants; 5.Heart rate less than 60 beats/min; 6.Patients with infection, ulcers, or scars on the auricle; 7. Severe spasms, i.e., modified Ashworth grade exceeding grade III; 8.Patients who cannot tolerate treatment or cannot cooperate with the follow-up of the trial progress.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FMA-LE scale score;Functional near-infrared spectroscopy imaging technology: brain functional connectivity; | — |
Secondary
| Measure | Time frame |
|---|---|
| MBI scale score;Modified Ashworth Scale scale score;Brunnstrom scale score;Hospital Anxiety and Depression Scale score; | — |
Countries
China
Contacts
Public ContactLitong Wang
The Second Affiliated Hospital of Dalian Medical University
Outcome results
None listed