Mechanism of cisplatin activating cancer associated fibroblasts (CAFs) through PAI-1 to promote platinum resistance in ovarian cancer

Mechanism of platinum induced PAI-1 mediated activation of CAFs leading to acquired drug resistance in ovarian cancer

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2500102624

Enrollment

Unknown

Registered

2025-05-16

Start date

2025-06-01

Completion date

Unknown

Last updated

2025-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ovarian cancer

Interventions

Observation group:None

Eligibility

Sex/Gender

Female

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.The research subject completed treatment in our hospital; 2.Clear postoperative pathology and clinical diagnosis; 3.Complete pathological data;

Exclusion criteria

Exclusion criteria: 1.Merge with other malignant tumors; 2.merge with a history of other systemic malignant tumors; 3.have coagulation related diseases; 4.Combining serious internal and surgical diseases; 5.preoperative radiotherapy, chemotherapy, or immunotherapy;

Design outcomes

Primary

Measure	Time frame
Fibroblast activation protein-a;PAI-1 protein level;	—

Secondary

Measure	Time frame
Volume and mass of subcutaneous tumors;	—

Countries

China

Contacts

Public ContactXiaoMing Xiong

The first affiliated hostipal of nanchang university

sgxiongxiaoming@163.com+86 132 9703 2250

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026