Perioperative depression in patients with breast tumor
Conditions
Interventions
S-ketamine group:Subjects in the observation group will receive a similar infusion rate of 0.6ml per hour per kilogram of body weight of ketamine in a 50ml syringe for 40 minutes.
Normal saline group:Forty minutes before the end of the surgery, subjects in the control group will be infused with 50ml of saline solution prepared in advance at a rate of 0.6ml per hour per kilogram
Sponsors
The First Affiliated Hospital of Xinjiang Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 65, body mass index (BMI) of 18-30 kg/m^2[BMI = weight (kg) / height (m)^2]; 2.ASA classification I-II, SDS self-rating depression scale score >53 points. 3.Expected surgical duration <=4 hours; 4.Good communication, willing to undergo regular follow-up after surgery.
Exclusion criteria
Exclusion criteria: 1.ASA III or higher, poorly controlled hypertensive patients, patients with aphasia or other conditions that may prevent proper mental assessment; 2.Postoperative need for maintained intubation; 3.History of psychosis or bipolar disorder; 4.Substance abuse history; body mass index (BMI) over 30; 5.History of antidepressant medication within 2 weeks prior to screening; 6.History of adverse events related to S-ketamine; 7.Currently pregnant or lactating.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Self-Rating Depression Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analog Scale; | — |
Countries
China
Contacts
Public ContactAilaitiTalaiti
The First Affiliated Hospital of Xinjiang Medical University
Outcome results
None listed