Postoperative delirium
Conditions
Interventions
Group D:Sedation with dexmedetomidine for patients transferred to the AICU after elective surgery under general anesthesia.
Group E:Sedation with esketamine for patients transferred to the AICU after elective surgery under general anesthesia.
Sponsors
Zhujiang Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) The subjects voluntarily cooperate with the study and sign the informed consent form; (2) No gender limitation, aged 60 to 90; (3) Transferred to AICU within 24 hours after elective surgery under general anesthesia; (4) Requires sedation treatment due to medical conditions.
Exclusion criteria
Exclusion criteria: 1.Uncontrolled or poorly controlled hypertension (systolic blood pressure >=180 mmHg or diastolic blood pressure >=110 mmHg) or intracranial hypertension; 2.Severe heart failure or second- or third-degree atrioventricular block; heart rate <55 bpm; 3.Acute coronary syndromes (e.g., unstable angina or acute myocardial infarction); 4.Glaucoma or penetrating eye injuries; 5.Untreated or inadequately treated hyperthyroidism or hypothyroidism; 6.Severe central nervous system diseases (e.g., acute stroke, uncontrolled epilepsy, severe dementia); 7.Allergy or contraindication to study drugs such as dexmedetomidine or esketamine and their components; 8.History of alcoholism, drug addiction, or substance abuse; 9.Severe visual or auditory impairments, or inability to communicate in Mandarin or Cantonese; 10.Severe preoperative infection; 11.Patients deemed unsuitable for participation by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of Anesthesia-Related Complications in the AICU;Postoperative recovery status;Changes in plasma inflammatory factor levels;Pain score; | — |
Countries
China
Contacts
Public ContactLi Le
Zhujiang Hospital of Southern Medical University
Outcome results
None listed