Anxiety and Depression
Conditions
Interventions
Test group H:1.0ug/kg Sufentanil +0.5mg/kg esketamine +5mg tropisetron +2ug/kg dexmetopidine was prepared into 100ml with sodium chloride and added to the postoperative analgesic pump
Test group L:1.0ug/kg Sufentanil +0.3mg/kg esketamine +5mg tropisetron +2ug/kg dexmetopidine was prepared into 100ml with sodium chloride and added to the postoperative analgesic pump
Control group:2.0ug/kg Sufentanil +5mg tropisetron +2ug/kg dexmetopil was prepared into 100ml with sodium chloride and added to the postoperative analgesic pump
Sponsors
Tangdu Hospital, Air Force Military Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for radical mastectomy under general anesthesia; 2. Age >= 18 years and < 65 years; BMI index 18 - 30 kg/m²; 3. ASA grade I to III; 4. Primary tumor, without radiotherapy or chemotherapy before surgery; 5. Voluntary signing of informed consent; 6. Preoperative SAS score greater than 50 points.
Exclusion criteria
Exclusion criteria: 1. A history of depression or other mental disorders before the operation; 2. Poor comprehension or communication barriers, unable to cooperate with the researcher; 3. Severe heart disease (cardiac function grade III or above); 4. Preoperative visit blood pressure >= 180/110 mm Hg (WHO-ISH grade 3 hypertension); 5. History of breast surgery; 6. Participants who have taken part in other clinical trials within the three months prior to being included in this study; 7. Other conditions deemed unsuitable for participation in this study by the attending physician or researcher (reasons must be recorded).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative depression self-rating scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative anxiety self-rating scale score;Postoperative nausea and vomiting score;Postoperative pain score;Serum tumor necrosis factor a(TNF-a) and interleukin-6 (IL-6) levels before and after surgery;Number of postoperative analgesic pump compressions; | — |
Countries
China
Contacts
Public ContactChangjun Gao
Tangdu Hospital, Air Force Military Medical University
Outcome results
None listed