None listed
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1.Planned for unilateral total knee arthroplasty using epidural anesthesia; 2.American Society of Anesthesiologists Physical Status (ASA PS) grades I-III; 3.Aged between 60-80 years; 4.Body Mass Index (BMI) between 18-40;
Exclusion criteria
Exclusion criteria: 1.Pathological diseases other than osteoarthritis of the knee (such as rheumatoid arthritis, traumatic arthritis, and septic arthritis); 2.Knee flexion deformity exceeding 30 degrees; varus or valgus deformity exceeding 30 degrees; 3.Unable to walk without the aid of assistive devices prior to surgery; 4.History of open knee surgery or treatment for knee infection; 5.Knee revision surgery; 6.Bilateral knee replacement; 7.Lack of communication ability; 8.Neuropathic pain or sensory disturbances in the surgical limb; 9.Known allergy to study drugs; 10.Varicose, skin lesions, scars, etc., at the site of adductor canal injection; 11.Chronic use of opioids, with a daily oral morphine milligram equivalent (MME) dose exceeding 30 mg;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative morphine consumption within 48 hours post-TKA surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS scores;Timed Up and Go test (TUG);The rate of complications; | — |
Countries
China
Contacts
The University of Hongkong - Shenzhen Hospital