Perioperative neurocognitive disorder
Conditions
Interventions
Sham Group:Sham-rTMS intervention
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years old; 2. Patients with preoperative mild to moderate cognitive impairment, defined as 92 hours; 4. Postoperative hospitalization is expected to exceed 5 days;
Exclusion criteria
Exclusion criteria: 1. Left-handed; 2. Primary school education level or below; 3. Comorbid severe mental illness, intellectual disability, auditory and visual dysfunction, language impairment, severe neurological disorders, or other diseases that cannot be cooperated in completing the study; 4. Craniocerebral surgery; 5. rTMS treatment contraindications such as epilepsy patients, pregnant or lactating women, or with a metal or electric implanted device (e.g., deep brain stimulator, ventriculoperitoneal shunt, aneurysm clip, pacemaker, cochlear, surgical staples on the scalp); 6. Other situations that the researcher deems unsuitable for inclusion in the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of delayed neurocognitive recovery on the 5th day after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of postoperative neurocognitive disorder on the 30th day after surgery;Pain scores within 5 days after surgery;The incidences of complications and mortality within 30 days after surgery;Survival within 180 days after surgery;The incidence of delirium within 5 days after surgery;Brain network functional connectivity on the 5th day after surgery;The incidence of postoperative neurocognitive disorder on the 130th day after surgery;Quality of life score on the 30th day and 180th day after surgery;The length of postoperative hospital stay; | — |
Countries
China
Contacts
Public ContactDongxin Wang
Peking University First Hospital
Outcome results
None listed