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Intestinal Dysbiosis Promotes the Development of Bronchopulmonary Dysplasia via the Gut-Lung Axis: A Study on Its Mechanisms

Intestinal Dysbiosis Promotes the Development of Bronchopulmonary Dysplasia via the Gut-Lung Axis: A Study on Its Mechanisms

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500102578
Enrollment
Unknown
Registered
2025-05-16
Start date
2024-10-28
Completion date
Unknown
Last updated
2025-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bronchopulmonary dysplasia

Interventions

BPD Group: Select infants with a gestational age of less than 32 weeks, who can be diagnosed as BPD at a corrected gestational age of 36 weeks:None
Control group: Select infants with a gestational age of less than 32 weeks, who can be excluded from BPD at a corrected gestational age of 36 weeks:None

Sponsors

Quanzhou Women's and Children's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Birth weight <1500g or gestational age <32 weeks; 2. Preterm infants with mechanical ventilation 24 hours after birth; 3. Obtain the informed consent of the infant's parents

Exclusion criteria

Exclusion criteria: 1. Congenital malformations (such as congenital heart disease, congenital digestive tract malformations); 2. Necrotizing enterocolitis; 3. Genetic metabolic diseases; 4. Parents request to withdraw from the experiment.

Design outcomes

Primary

MeasureTime frame
Pulmonary-intestinal microbiota signature;—

Secondary

MeasureTime frame
The levels of short-chain fatty acids in feces;—

Countries

China

Contacts

Public ContactFang Lingyu

Quanzhou Women's and Children's Hospital

443516862@qq.com+86 96665893

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026