Moderate to Severe Crohn's Disease
Conditions
Interventions
Sequential Nutritional Therapy Group:Sequential Functional Nutrition
Control group:Free diet
Sponsors
Tianjin Children Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.According to the Chinese Medical Association "Expert consensus on the diagnosis and treatment of inflammatory bowel disease in children", the diagnosis was consistent with CD. 2.Moderate to severe CD, pediatric Crohn's disease activity index (PCDAI) >=30; 3.Active inflammation at enrollment (C-reactive protein > 5g/L, or erythrocyte sedimentation rate > 20mm/h, or calprotectin > 200µg/g); 4.Parents voluntarily participated and signed informed consent; 5.The patients were treated according to the "Expert consensus on the diagnosis and treatment of inflammatory bowel disease in children" and the clinical pathway of CD in our hospital.
Exclusion criteria
Exclusion criteria: 1.Children with other intestinal diseases or intestinal trauma; 2.in the respiratory tract, digestive tract and other infection period or cured within 1 month; 3.use of probiotics/fecal microbiota transplantation or drug withdrawal within 1 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cytokines: CRP, ESR, CALPR, TNF-a, IL-1ß, IL-6, IL-8, IL-10, IL-12, IL-17, IL-22, IFN-?, I-FABP, D-LAC, LPS, DAO, T cell subgroups; | — |
Countries
China
Contacts
Public ContactYing Lin
Tianjin Children Hospital
Outcome results
None listed