Epithelial varian cancer
Conditions
Interventions
Gold Standard:patoegtel dagnesk
Sponsors
The First Medical Center of the PLA General Hospital
Eligibility
Sex/Gender
Female
Age
35 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Women aged 35 years or older; 2. Women carrying BRCA1/2 germline mutations or carrying HRR-related mutations (such as germline mutations of RAD51C, RAD51D, BRIP1, PALB2, ATM, etc., and mutations of BARD1, BRIP1, CHEK2, MRE11A, MSH6, NBN, PALB2, RAD50, RAD51C, or TP53, etc.), or patients with Lynch syndrome; 3. Having pelvic imaging evaluation results, including ultrasound, MRI, CT or PET/CT; 4. Having sufficient samples for serological marker examination; 5. Volunteering to participate in this study and signing the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pregnant and lactating women; 2. Women who have regular follow-up examinations after ovarian cancer surgery; 3. Patients with recurrent ovarian cancer diagnosed by the researchers; 4. Patients who are undergoing chemotherapy or pelvic radiotherapy treatment courses; 5. Patients with other diagnosed primary malignant tumors; 6. Contraindications for surgical evaluation and inability to obtain ovarian pathological or surgical pathological information; 7. Samples that do not meet the requirements for collection and storage of the evaluation reagent samples; 8. Contaminated or suspected to be contaminated samples; 9. Samples with missing, incomplete or untraceable corresponding patient clinical data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sensitivity;specificity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Positive predictive value;Negative predictive value;Area under ROC curve; | — |
Countries
China
Contacts
Public ContactYe Mingxia
The First Medical Center of the PLA General Hospital
Outcome results
None listed