Exocrine Pancreatic Insufficiency
Conditions
Interventions
Control group:None
Sponsors
The Second Hospital of Lanzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) Aged 18–70 years; 2) Having undergone cholecystectomy (laparoscopic or open) with a postoperative period of =6 months; 3) Voluntarily participating and signing the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Individuals with abnormal routine stool examination results; 2) Patients with severe constipation or inability to defecate voluntarily; 3) Pregnant or lactating women; 4) Patients with malignancies, high fever, severe infections, or severe cardiac, cerebral, hepatic, or renal disorders; 5) Individuals with organic gastrointestinal diseases or a history of gastrointestinal surgery; 6) Patients with gastrointestinal bleeding; 7) Cases of gastrointestinal outflow obstruction or mechanical ileus; 8) Patients with conditions affecting digestion/absorption (e.g., inflammatory bowel disease, liver cirrhosis); 9) Individuals with systemic metabolic disorders (e.g., thyroid dysfunction, diabetes mellitus, hyperlipidemia); 10) Patients with a history of acute/chronic pancreatic diseases, pancreatic surgery, or pancreatic trauma; 11) Use of somatostatin, aprotinin, or drugs known to induce/exacerbate pancreatic exocrine insufficiency within the past 2 weeks; 12) Use of medications altering fat absorption (e.g., Orlistat, other weight-loss drugs, ursodeoxycholic acid) within the past 2 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fecal elastase-1,FE-1; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gastrointestinal quality of life index,GIQLI;Gastrointestinal Symptom Rating Scale,GSRS; | — |
Countries
China
Contacts
Public ContactGuoqing Qi
The Second Hospital of Lanzhou University
Outcome results
None listed