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To explore the neuropathological mechanism of primary trigeminal neuralgia based on multimodal MRI and construct the clinical imaging efficacy prediction model

To explore the neuropathological mechanism of primary trigeminal neuralgia based on multimodal MRI and construct the clinical imaging efficacy prediction model

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500102556
Enrollment
Unknown
Registered
2025-05-16
Start date
2025-05-20
Completion date
Unknown
Last updated
2025-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Trigeminal neuralgia

Interventions

Test group:None
control group:None

Sponsors

The Second Hospital & Clinical Medical School, Lanzhou University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Meet the International Classification of Headache Disorders (ICHD-3) diagnostic criteria for ITN and CTN; Age of patients > 18 years old, < 75 years old; Right-handed; Unilateral pain in the trigeminal innervation area; Stinging or shock-like pain caused by the mouth and facial trigger area; No significant neurological disorders or sensory deficits were found after clinical evaluation.

Exclusion criteria

Exclusion criteria: STN confirmed by MR; Other types of pain disorders; Suffering from a major mental illness; In the past, she has performed craniocerebral surgery such as MVD. Patients with substance addiction; He has contraindications to MR Examination and cannot tolerate prolonged MR Examination.

Design outcomes

Primary

MeasureTime frame
white matter diffusion parameters based on NODDI;the contents of GABA and Glx in the thalamus;fMRI functional connectivity parameters of pain-related brain regions;

Secondary

MeasureTime frame
visual analog scale scoring;mcgillPain questionnaire scoring;self-rating anxiety scale scoring;self-rating depression scale scoring;

Countries

China

Contacts

Public ContactZhang jing

The Second Hospital & Clinical Medical School, Lanzhou University

zhangjing3068@163.com+86 186 4511 7793

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026