Adverse reactions to opioids
Conditions
Interventions
Opioid group:Induction with Succinylcholine 0.2-0.4 ug/kg, Propofol 1.5-2.0 mg/kg, Rocuronium 0.6 mg/kg, maintenance with Remifentanil 0.1-0.2 ug/kg/min and Propofol 2-10 mg/kg/h.
Non-opioid group:Induction with esketamine 0.2-0.4 mg/kg, propofol 1.5-2.0 mg/kg, rocuronium 0.6 mg/kg-1.0 mg/kg, lidocaine 1 mg/kg
maintenance with esketamine 0.1 mg/kg/h, propofol 2-10 mg/kg/h, dexmedetomidine 0.3-1.0 ug/kg/h.
Sponsors
The First Hospital Of Jiaxing
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Short surgery under general anesthesia at our hospital (<90 minutes); 2. Elderly patients over 60 years old; 3. ASA1-3 level 4. General anesthesia patients
Exclusion criteria
Exclusion criteria: 1. Patients undergoing epidural anesthesia; 2. Severe cardiovascular diseases (such as unstable angina and NYHA III-IV heart failure); 3. Severe liver and kidney dysfunction (such as Child Pugh C grade eGFR 9%); 5. Active infection or immunosuppression status; 6. Long term use of opioid drugs before surgery (such as in patients with chronic pain) or a history of opioid dependence; 7. Allergies or contraindications to experimental drugs (such as propofol, dexmedetomidine, ketamine, etc.); 8. Moderate to severe cognitive impairment (such as MMSE score2 hours) or transferred to open surgery; 10. Emergency surgery or combined surgery with other organs; Participate in other clinical trials or refuse to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite endpoints for opioid-related adverse events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of stay;Intraoperative hemodynamic stability;PACU stay time;Pain score;Extubation time;Whether emergency antiemetic and analgesic drugs are needed; | — |
Countries
China
Contacts
Public ContactHuadong Ni
The First Hospital Of Jiaxing
Outcome results
None listed