Colorectal Polyp
Conditions
Interventions
A:Intravenous injection of propofol 0.3mg/kg + esketamine 0.2mg/kg,The continuous pump infusion adopts the sequential method: the Dixon sequential method is used for the test. The initial dose of the
B:Intravenous injection of propofol 0.3mg/kg,The continuous pump infusion adopts the sequential method: the Dixon sequential method is used for the test. The initial dose of the first patient to recei
Sponsors
Shanghai Xuhui Central Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age 65-75 years old; 2.Patients who are planning to undergo ESD for colon polyps; 3.The operation time is less than 1 hour; 4.American Society of Anesthesiologists (ASA) grade I-II; 5.Body Mass Index (BMI) 20-25. 6.Mallampati grade I-II.
Exclusion criteria
Exclusion criteria: 1.Patients with severe systemic diseases, such as liver and kidney dysfunction, cardiovascular and cerebrovascular diseases, immune system diseases, etc. 2.Patients with alcoholism, drug dependence, history of mental illness or neurological diseases (Alzheimer's disease, stroke and abnormal psychology); 3.Patients with surgical procedures changed due to patient reasons; 4.Patients who are allergic to esketamine or propofol and any ingredients in their formulations. 5.Patients with upper airway abnormalities, respiratory insufficiency or sleep apnea that may cause dyspnea.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Dosage of cyclopofol while Postive reaction occures; | — |
Secondary
| Measure | Time frame |
|---|---|
| heart rate;MAP;SPO2;Anesthesia onset time;Total intraoperative dose of propofol;Dosage of vasoactive drugs during surgery;wake time; | — |
Countries
China
Contacts
Public ContactIlyar Mamtili
Shanghai Xuhui Central Hospital
Outcome results
None listed