Epilepsy and related Cognitive Impairment
Conditions
Interventions
Intervention group:Single-session stimulation parameters: frequencies: f1 = 2 kHz, f2= 2.005 kHz
current intensity: 2 mA (within the safe range for human application)
Duration: 30 minutes. Continuous stimulation protocol: consistent with single-session stimulation (f1 = 2 kHz, f2= 2.005 kHz
current intensity: 2 mA
Duration: 30 minutes), once daily, 14 consecutive days.
Sponsors
The second affiliated hospital of Army medical university
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis meeting the criteria for drug-resistant epilepsy (DRE). 2. Age between 18–60 years, with no gender restrictions. 3. Cognitive impairment defined by the Addenbrooke’s Cognitive Examination-III (ACE-III): 1–9 years of education: Score 16 years of education: Score < 80; Intact communication ability (verbal/written). 4. No history of traumatic brain injury or other severe neurological disorders (except epilepsy). 5. No prior neuromodulation therapy (e.g., TI-TES, tDCS, rTMS). 6. Written informed consent obtained after full disclosure of alternative treatments and potential risks.
Exclusion criteria
Exclusion criteria: 1. Presence of psychiatric, cognitive, or psychological disorders that impair the ability to provide informed consent or comply with testing procedures. 2. Patients with secondary epilepsy due to cerebrovascular disease, tumors, infections, or autoimmune disorders. 3. Medication use: Current use of drugs that may alter central nervous system (CNS) function. 4. Skin conditions: Active skin infections, wounds, or lesions at the neurostimulation device contact sites. 5. Substance dependence: History of drug abuse or alcohol dependence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in SEEG, ACE-III cognitive assessment scores of epilepsy patients on stimulation day compared to baseline (pre-stimulation); | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in SEEG, ACE-III scores of epilepsy patients at one month after two-week continuous stimulation compared to baselineChanges in ACE-III scores of epilepsy patients at one month after two-week continuous stimulation compared to baseline;Changes in reaction time and accuracy rate on memory and decision-making paradigm tests in epilepsy patients on stimulation day compared to baseline;Changes in SEEG, ACE-III scores, reaction time and accuracy rate on memory and decision-making paradigm tests in epilepsy patients at one month after two-week continuous stimulation compared to baseline; | — |
Countries
China
Contacts
Public ContactZhang Chun-Qing
The second affiliated hospital of Army medical university
Outcome results
None listed