atrial fibirllation
Conditions
Interventions
ARNI group:After RFCA, ACEIs and ARNIs were administered to the control group and the ARNI group, respectively. The patients in the control group who experienced intolerable coughing symptoms due to A
control group:For patients in the control group, the initial dosage of 2-4 mg of perindopril or 40mg of valsartan once daily and the dosage can be doubled every 2-4 weeks until gradually titraed to th
Sponsors
Wujin Hospital Affiliated with Jiangsu University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Persistent atrial fibrillation (duration >7 days but 1 year); 2.Resistance to at least one antiarrhythmic drug; 3. Left atrial diameter (LAD) <=55 mm; 4. History of hypertension or hypertension at admission; 5. First-time atrial fibrillation ablation; 6. Those with poor left atrial substrate .
Exclusion criteria
Exclusion criteria: 1. Age 85 years; 2. Pregnancy or lactation in females; 3. Previous radiofrequency ablation or surgical intervention for arrhythmia; 4. Atrial fibrillation duration >5 years; 5. Significant structural heart disease (e.g., hypertrophic cardiomyopathy, dilated cardiomyopathy, severe valvular heart disease); 6. History of myocardial infarction; 7. Life expectancy <1 year; 8 Known hereditary angioedema or history of angioedema related to ACE inhibitors/ARBs and allergy to sacubitril/valsartan or its components; 9. Use of ARNI within the past week; 10. Inability to obtain informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint of the study was freedom from AF or AT/AFL 12 months postablation; | — |
Secondary
| Measure | Time frame |
|---|---|
| recurrence types;systolic blood pressure (SBP);diastolic blood pressure (DBP);left atrial internal diameter (LAD);left ventricular end-diastolic diameter (LVEDD);left ventricular ejection fraction (LVEF);NT-proBNP;major adverse cardiac events (MACEs); | — |
Countries
China
Contacts
Public ContactWenhua Li
Wujin Hospital Affiliated with Jiangsu University
Outcome results
None listed