Effects of tagileridine fumarate vs sufentanil citrate on remifentanil-induced hyperalgesia after thoracoscopic surgery

Effects of tagileridine fumarate vs sufentanil citrate on remifentanil-induced hyperalgesia after thoracoscopic surgery - Effects of tagileridine fumarate vs sufentanil on remifentanil-induced hyperalgesia after thoracoscopic surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500102507

Enrollment

Unknown

Registered

2025-05-15

Start date

2026-02-26

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing thoracoscopic surgery

Interventions

T group:After stopping the pump injection of remifentanil, administer 1mg of Teligidine intravenously

S group:After stopping the pump injection of remifentanil, administer 10µg of sufentanil intravenously

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 18-65 years old ASA grade I-II Elective thoracoscopic surgery is planned to be performed

Exclusion criteria

Exclusion criteria: The patient refused to use the postoperative analgesic pump, was unable to understand the pain threshold measurement assessment and pain assessment, used opioid drugs before the operation, had a history of chronic pain, a history of drug abuse, and was allergic to the drugs needed for the study

Design outcomes

Primary

Measure	Time frame
The pain threshold around the incision 6 hours after the surgery;	—

Secondary

Measure	Time frame
Preoperative pain threshold around the incision;The pain threshold around the incision 24 hours after the surgery;The pain threshold around the incision 48 hours after the surgery;Preoperative pain threshold on the non-dominant arm side;The pain threshold on the non-dominant arm side 6 hours after the surgery;The pain threshold on the non-dominant arm side 24 hours after the surgery;The pain threshold on the non-dominant arm side 48 hours after the surgery;NRS pain scores at 6 hours, 24 hours and 48 hours after the surgery;The additional frequency of the self-controlled analgesic pump;The dosage of fentanyl before leaving the PACU;The dosage of fentanyl 48h after the surgery;the times of remediate analgesia at 48 hours after the surgery;adverse events after the surgery;The intraoperative administration of remifentanil ;surgery duration, anesthesia duration;	—

Measure

Time frame

Preoperative pain threshold around the incision;The pain threshold around the incision 24 hours after the surgery;The pain threshold around the incision 48 hours after the surgery;Preoperative pain threshold on the non-dominant arm side;The pain threshold on the non-dominant arm side 6 hours after the surgery;The pain threshold on the non-dominant arm side 24 hours after the surgery;The pain threshold on the non-dominant arm side 48 hours after the surgery;NRS pain scores at 6 hours, 24 hours and 48 hours after the surgery;The additional frequency of the self-controlled analgesic pump;The dosage of fentanyl before leaving the PACU;The dosage of fentanyl 48h after the surgery;the times of remediate analgesia at 48 hours after the surgery;adverse events after the surgery;The intraoperative administration of remifentanil ;surgery duration, anesthesia duration;

—

Countries

China

Contacts

Public ContactLin Jingyan

Affiliated Hospital of North Sichuan Medical College

Linjingyan@nsmc.edu.cn+86 159 8377 1119

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 14, 2026