Hepatitis C, syphilis
Conditions
Interventions
Control group:Facility-based HCV testing
Intervention group:HCV reflex testing
Control group:No intervention
Intervention group:HCV self-testing secondary distribution model
Sponsors
Guangdong Provincial Center for Disease Control and Prevention
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Sub project 1: Male to male sexual activity: 1. Have had sexual intercourse with someone of the same sex before, 2. Age 18 years old or above, 3. Physiological sex male, 4. Have not undergone syphilis or hepatitis C testing in the past 6 months, 5. Have not been diagnosed with syphilis or hepatitis C infection in the past 6 months, 6. Clearly express willingness to participate in this study and sign an informed consent form. 2. Sub project 1: Female sex workers: 1. Age 18 years old and above, 2. Physiological gender female, 3. Have engaged in commercial sexual activity in the past 6 months, 4. Have not undergone syphilis or hepatitis C testing in the past 6 months, 5. Have not been diagnosed with syphilis or hepatitis C infection in the past 6 months, 6. Clearly express willingness to participate in this study and sign an informed consent form. 3. Sub project 1: Male STD clinic visitors: 1. Age 18 years and above, 2. Physiological gender male, 3. On site STD clinic visitors, 4. No syphilis or hepatitis C testing in the past 6 months, 5. No diagnosis of syphilis or hepatitis C infection in the past 6 months, 6. Clearly express willingness to participate in this study and sign an informed consent form. 4. One person interview for sub projects: 1. Age 18 years old or above, 2. Participated in the "syphilis and hepatitis C relay test" project, 3. Does not suffer from serious mental or neurological disorders, 4. Able to provide informed consent. 5. Sub project 2: 1. Age 18 years old and above; 2. Diagnosed with hepatitis C infection within the past 6 months through hepatitis C nucleic acid testing; 3. Willing to apply for hepatitis C testing; 4. Willing to conduct follow-up visits; 5. Willing to sign an informed consent form. 6. Sub project 3: 1. Age 18 years old and above; 2. Proactively seeking or planning to undergo hepatitis C antibody testing; 3. Currently not diagnosed with hepatitis C infection; 4. Willing to participate and able to conduct follow-up on time; 5. Willing to sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Sub project 1: Male to male sexual activity: 1. Never had sexual intercourse with someone of the same sex, 2. Under 18 years old, 3. Female biological sex, 4. Tested for syphilis and hepatitis C in the past 6 months, 5. Diagnosed with syphilis or hepatitis C infection in the past 6 months, 6. unwilling to participate in this study or sign informed consent form, 7. Previously participated in the "syphilis and hepatitis C relay testing" project. 2. Sub project 1: Female sex workers: 1. Age under 18 years old, 2. Male biological sex, 3. No commercial sexual activity in the past 6 months, 4. Have undergone syphilis and hepatitis C testing in the past 6 months, 5. Diagnosed with syphilis or hepatitis C infection in the past 6 months, 6. unwilling to participate in this study or unwilling to sign informed consent form, 7. Previously participated in the "syphilis and hepatitis C relay testing" project. 3. Sub project 1: Male STD clinic visitors: 1. Age under 18 years old, 2. Physiological gender female, 3. Non STD clinic visitors, 4. Syphilis and hepatitis C testing conducted in the past 6 months, 5. Diagnosed with syphilis or hepatitis C infection in the past 6 months, 6. Refusal to participate in this study or sign informed consent form, 7. Previous participation in the "Syphilis and Hepatitis C Relay Testing" project. 4. Interview with one person for sub projects: 1. Age under 18 years old, 2. Have not participated in the "syphilis, hepatitis C relay test" project, 3. Suffering from serious mental or neurological disorders, 4. Unable to provide informed consent. 5. Sub project 2: 1. Age under 18 years old; 2. Not diagnosed with hepatitis C infection within the past 6 months; 3. Not willing to apply for hepatitis C testing; 4. Not willing to undergo follow-up; 5. Refuse to sign the informed consent form. 6. Sub project 3: 1. Age under 18 years old; 2. Those who are unwilling to undergo hepatitis C antibody testing; 3. Currently diagnosed with hepatitis C infection; 4. Not willing to participate or unable to complete follow-up; 5. Not willing to sign an informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time interval from detection of HCV antibody positivity to confirmation of HCV RNA positivity among HCV antibody-positive individuals in each group;Proportion of HCV-diagnosed individuals who return to the healthcare facility for confirmatory counseling in each group;The actual distribution numbers of HCV testing kits by indexs in each group;The time interval from diagnosis to initiating treatment among HCV-diagnosed individuals in each group;Number of alters returning test results in each group;Syphilis and HCV testing rate among participants in each group; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of newly-tested alters motivated by each index;The time interval from confirmatory counseling to initiation of antiviral therapy among HCV-confirmed individuals in each group;Proportion of HCV RNA testing in the control group;Number of HCV testing kits ordered by indexs in each group;Proportion of initiating antiviral treatment among HCV-confirmed individuals in each group;Amount of donated by participants in the intervention arm;Number of alters with HCV-positive results identified by each index;HCV RNA positivity among participants in each group;Proportion of participants donated for others for Syphilis and HCV testing in the intervention arm;The amount of participants who tested positive for syphilis and hepatitis C in each group; | — |
Countries
China
Contacts
Public ContactTang Weiming
Guangdong Provincial Center for Disease Control and Prevention
Outcome results
None listed