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Evaluation of the Efficacy of Intranasal Dexmedetomidine at Various Doses in Combination with Sevoflurane for Endotracheal Intubation without Muscle Relaxant in Pediatric Patients

Evaluation of the Efficacy of Intranasal Dexmedetomidine at Various Doses in Combination with Sevoflurane for Endotracheal Intubation without Muscle Relaxant in Pediatric Patients

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500102500
Enrollment
Unknown
Registered
2025-05-15
Start date
2025-06-01
Completion date
Unknown
Last updated
2025-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pediatric patients scheduled for elective surgery involving high ligation of the hernial sac via laparoscopy or for concealed penis correction"

Interventions

MD group:Dexmedetomidine 3 µg/kg nasal drops
LD group:Dexmedetomidine 2 µg/kg nasal drops
HD group:Dexmedetomidine 4 µg/kg nasal drops
SLD group:Dexmedetomidine 1 µg/kg nasal drops

Sponsors

The First People’s Hospital of Jingzhou
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Years to 5 Years

Inclusion criteria

Inclusion criteria: 1.Elective surgeries involving either high ligation of the hernial sac via laparoscopy or correction of concealed penis; 2.ASA physical status classification I–II; 3.Mallampati airway classification I–II; 4.age between 1 and 5 years;

Exclusion criteria

Exclusion criteria: 1.Patients with preoperative respiratory tract infections; 2.Patients with known allergies to dexmedetomidine or sevoflurane; 3.Patients who have received sedative or anesthetic drugs prior to surgery; 4.Patients with growth retardation or congenital heart defects; 5.Patients diagnosed with central nervous system diseases; 6.Patients with severe infections; 7.Patients with severe cardiac, cerebral, hepatic, renal, pulmonary, or endocrine diseases;

Design outcomes

Primary

MeasureTime frame
first-attempt intubation success rate;Postoperative sedation score;Anesthesia induction time;

Secondary

MeasureTime frame
Immediate heart rate and blood pressure values upon endotracheal intubation;Complications during intubation (such as laryngospasm, coughing, etc.);Time in postoperative recovery;

Countries

China

Contacts

Public ContactRui Xia

The First People’s Hospital of Jingzhou

879560350@qq.com+86 18972161338

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026