Cognitive impairment
Conditions
Interventions
Group A:Repetitive Transcranial Magnetic Stimulation, rTMS. First carry out 28 days of true stimulation, followed by 5 weeks of washout, and then conduct 28 days of sham stimulation.
Group B:Repetitive Transcranial Magnetic Stimulation, rTMS . First carry out 28 days of sham stimulation, followed by 5 weeks of washout, and then conduct 28 days of true stimulation.
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age between 50 and 80 years, with an educational level above primary school. 2. A score of >= 18 on the Mini-Mental State Examination (MMSE), with a clinical diagnosis of mild cognitive impairment. 3. No clinical seizures in the two days prior to high-density electroencephalography (EEG) monitoring, and no consumption of caffeine, nicotine, alcohol, medications, or illicit drugs within 24 hours before the experiment, with adequate sleep. 4. Right-handedness as determined by the Chinese handedness assessment criteria. 5. Normal hearing on initial physical examination.
Exclusion criteria
Exclusion criteria: 1. Individuals who have previously received treatments such as transcranial direct current stimulation, repetitive transcranial magnetic stimulation, trigeminal nerve stimulation, vagus nerve stimulation, or deep brain stimulation, or those with implanted cardiac pacemakers or other metallic devices. 2. Presence of skull defects, or progressive neurological diseases such as brain tumors or encephalitis. 3. Uncontrolled seizures, or a history of status epilepticus within the past six months. 4. Severe medical comorbidities, or pregnancy. 5. Severe psychiatric disorders such as major depression, or auditory or language impairments that preclude cooperation in completing the trial and assessments. 6. Structural abnormalities on imaging that are associated with epilepsy. 7. History of alcohol abuse or drug misuse. 8. Other patients deemed by the investigators to require exclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Phase Locking Value,PLV; | — |
Secondary
| Measure | Time frame |
|---|---|
| MMSE;Montreal Cognitive Assessment Score, MoCA; | — |
Countries
China
Contacts
Public ContactJing Ding
Zhongshan Hospital, Fudan University
Outcome results
None listed