Mother-to-child Transmission of Hepatitis B
Conditions
Interventions
Group A:pregnant women who initiate antiviral treatment at 20 week of pregnant(Tenofovir disoproxil fumarate or tenofovir alafenamide fumarate )
Group B:pregnant women who initiate antiviral treatment at 24 week of pregnant(Tenofovir disoproxil fumarate or tenofovir alafenamide fumarate )
Group C:pregnant women who initiate antiviral treatment at 28 week of pregnant(Tenofovir disoproxil fumarate or tenofovir alafenamide fumarate )
Group D:HBV infected women who had given birth in our hospital and had taken antiviral drugs throughout the pregnancy and their children
Sponsors
Beijing Ditan Hospital, Capital Medical University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Part one: pregnant women under the age of 30 with extremely high HBV DNA levels; Part two: HBV infected women who had given birth in our hospital and had taken antiviral drugs throughout the pregnancy and their children
Exclusion criteria
Exclusion criteria: Part one: 1. coinfected with other viral , such as HCV, syphilis, HIV, CMV, EBV, etc; 2. Female age greater than or equal to 30 years old; 3. Pregnant women with cirrhosis or liver cancer 4. Long term alcohol abuse and/or other liver damaging drugs; 5. Serious diseases of the heart, brain, lungs, kidneys, and other systems. 6. Not willing to participate in this study Part two: 1. coinfected with other viral , such as HCV, syphilis, HIV, CMV, EBV, etc; 2. Pregnant women with incomplete clinical data; 3. Pregnant women with cirrhosis or liver cancer 4. Long term alcohol abuse and/or other liver damaging drugs; 5. Serious diseases of the heart, brain, lungs, kidneys, and other systems. 6. Not willing to participate in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of HBV mother-to-child transmission;Child Development Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver function;Kidney function;Blood fat;Hemoglobin; | — |
Countries
China
Contacts
Public ContactYi Wei
Beijing Ditan Hospital, Capital Medical University
Outcome results
None listed