Helicobacter pylori infection
Conditions
Interventions
Vonoprazan-minocycline combination:Treatment plan:Vonoprazan 20mg bid + Minocycline 0.1g bid for 14 days
Vonoprazan-amoxicillin combination:Treatment plan:Vonoprazan 20mg bid +Amoxicillin 1g tid for 14 days
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-75 years old, male or female. 2. Positive C13 or C14 breath test within one month. 3. Meet the indications for the eradication of Hp as recommended by the "Sixth National Consensus Report on the Management of Helicobacter pylori Infection and are willing to receive Hp eradication therapy. 4. No history of Hp eradication therapy. 5. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. patients allergic to the drugs used in this study; 2. use of P-CAB, PPI, H2 receptor antagonist, antibiotics bismuth, probiotics, etc. within 1 month before treatment; 3. women who are pregnant or breastfeeding, and patients planning for pregnancy during the study period; 4. use of non-steroidal anti-inflammatory drugs, glucocorticoids, anticoagulants during the study period; 5. the presence of severe concomitant affecting the evaluation of this study, such as heart disease, pulmonary disease, liver disease, renal disease, metabolic disease, mental disease, malignant tumor, etc.; 6. patients who are difficult to follow up or have other factors affecting compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Helicobacter pylori eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse reactions;Drug adherence; | — |
Countries
China
Contacts
Public ContactFeng Huang
The First Affiliated Hospital of Soochow University
Outcome results
None listed