Lumbar Vertebral Fracture/Spondylolisthesis
Conditions
Interventions
Experimental Group:At the conclusion of surgery, oliceridine 0.02 mg/kg is administered intravenously. The patient-controlled analgesia (PCA) pump protocol is configured as follows:
Oliceridine 0.3 m
Control Group:At the conclusion of surgery, fentanyl 0.001 mg/kg is administered intravenously. The patient-controlled analgesia (PCA) pump protocol is configured as follows:
Fentanyl 0.015 mg/kg + gr
Sponsors
The Affiliated Hospital of Panzhihua University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1)Aged between 18 and 65 years; (2)ASA physical status classification of I-II; (3)Scheduled for elective internal fixation for lumbar fracture or lumbar spinal fusion; (4)BMI between 18.5 and 28 kg/m²; (5)Signed informed consent form obtained.
Exclusion criteria
Exclusion criteria: (1)Chronic pain requiring long-term analgesic use; (2)Severe pulmonary hypertension, hepatic or renal dysfunction, or concurrent severe respiratory/cardiovascular diseases; (3)Abnormal ECG findings (e.g., sick sinus syndrome, second-degree or higher atrioventricular block, atrial fibrillation, QT interval prolongation >450 ms); (4)History of chronic alcoholism; (5)Pregnancy, lactation, or plans for pregnancy in the near future; (6)Psychiatric disorders or communication barriers; (7)Specific cases requiring postoperative tracheal intubation and transfer to the intensive care unit (ICU); (8)Investigator-deemed ineligibility.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 Questionnaire Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative Rocuronium Consumption and Extubation Time;PACU Rescue Analgesic Consumption;NRS Pain Score at Rest;Number of PCA administrations by the patient in 24 hours;24-hour consumption of analgesics;Use of rescue analgesics over 24 hours;Patient satisfaction; | — |
Countries
China
Contacts
Public ContactFeng Zhu
The Affiliated Hospital of Panzhihua University
Outcome results
None listed