Pediatric Surgery
Conditions
Interventions
Group 2:0.1mg/ kg esketamine
Group 3:0.3mg/ kg esketamine
Group 1:0 mg/ kg esketamine
Group 4:0.5mg/ kg esketamine
Group 5:0.7mg/ kg esketamine
Sponsors
Linping District Women and Children Care Hospital ,Zhejiang,Hangzhou
Eligibility
Sex/Gender
All
Age
1 Years to 4 Years
Inclusion criteria
Inclusion criteria: Children aged 1 to 4 years, of any sex, classified as ASA I–II, scheduled to undergo elective laparoscopic inguinal hernia repair under general anesthesia, and requiring preoperative sedation. Inclusion criteria also required a Parental Separation Anxiety Score (PSAS) of >=3 on two occasions in the preoperative holding area.(PSAS: 1 = easy separation; 2 = whimpers but easily calmed; 3 = crying and not easily calmed; 4 = crying and clinging tightly to parents).
Exclusion criteria
Exclusion criteria: Children with known allergy to midazolam, esketamine, or ketamine; those with respiratory tract infection, central nervous system dysfunction, cardiovascular dysfunction, or gastrointestinal disease; children undergoing surgery lasting >=90 minutes; obese children weighing more than 30 kg; emergency surgeries; or children whose guardians declined participation were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Preoperative Separation Anxiety Score;secretion;Respiratory depression;3-minute separation anxiety score;Surgical duration;Wake up duration;Nausea and vomiting; | — |
Countries
China
Contacts
Public ContactSufeng Lin
Maternal and Child Health Hospital, Linping District, Hangzhou, Zhejiang Province
Outcome results
None listed