Chronic kidney disease Stage 5
Conditions
Interventions
Experimental group:Hemoperfusion
Control group:None
Sponsors
Renji Hospital affiliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.18-75 years old, regardless of gender; 2.Maintenance hemodialysis (>=3 months) and blood purification treatment 3 times a week; 3.The vascular access was autologous arteriovenous fistula or artificial vessels, and the blood flow was =200mL/min; 4.spKT/V>=1.2; 5.Voluntarily sign informed consent;
Exclusion criteria
Exclusion criteria: 1.Patients who have participated in other clinical studies within 1 month; 2.Pregnant or lactating women; 3.Patients with a New York College of Cardiology (NYHA) grade 4 or who had acute coronary syndrome or myocardial infarction within 3 months prior to study start; 4.Patients with active bleeding within 2 weeks (such as cerebral hemorrhage, digestive tract hemorrhage, fundus hemorrhage, etc.); 5.Patients with low blood pressure (pre-dialysis blood pressure =140g/L); 6.Patients with severe infections (hypersensitive C-reactive protein levels 10 times higher than the upper limit of normal); 7.Platelet count < 60×109/L or white blood cell count < 4×109/ L; 8.Patients with a history of drug addiction or serious mental disorders; 9.Other investigators considered that they could not participate in the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ? free light chain;Tumor necrosis factor-a;Fibroblast growth factor23;Interleukin-6;YKL-40; | — |
Secondary
| Measure | Time frame |
|---|---|
| P-Cresol;YKL-40;Tumor necrosis factor-a;Interleukin-6;Fibroblast growth factor23;Indoxyl sulfate;? free light chain; | — |
Countries
China
Contacts
Public ContactRenhua Lu
Renji Hospital affiliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed