The Application of Quantitative Analysis of Pupillary Light Reflex in Predicting Visual Prognosis of Retinal Detachment and Relevant Model Construction

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2500102386

Enrollment

Unknown

Registered

2025-05-14

Start date

2025-06-01

Completion date

Unknown

Last updated

2025-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Retinal Detachment

Interventions

case cohort:NA

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Newly diagnosed patients (aged 18-70 years) with unilateral rhegmatogenous retinal detachment who consented to participate in the study. 2. Scheduled to undergo retinal detachment repair surgery including pars plana vitrectomy alone or combined anterior-posterior segment procedures. 3. Absence of pupillary synechiae or other abnormalities affecting pupillary light reflex measurements in either eye. 4. Availability of complete medical records and imaging data with adequate quality for quantitative analysis. 5. Ability to complete scheduled follow-up examinations at 1, 3, and 6 months postoperatively.

Exclusion criteria

Exclusion criteria: 1. Macular hole-related retinal detachment, retinal detachment with choroidal detachment, or combined traction-rhegmatogenous detachment secondary to proliferative diabetic retinopathy. 2. Monophthalmic patients or those with media opacities precluding fundus examination. 3. Coexisting sight-threatening ocular pathologies in either eye, including: Retinal vein occlusion, Diabetic retinopathy, Retinitis pigmentosa, Epiretinal membrane, Macular hole, Neovascular age-related macular degeneration, Uveitis, Glaucoma. 4. Systemic conditions (e.g., stroke, cardiovascular events) or other factors compromising pupillary light reflex assessment. 5. Incomplete medical records or imaging data. 6. Postoperative failure of anatomical retinal reattachment.

Design outcomes

Primary

Measure	Time frame
Maximum Pupillary Constriction Amplitude;Pupillary Constriction Latency;Pupillary Constriction Velocity;Maximum Constriction Amplitude Percentage;Pupillary Maximum Constriction Latency;Pupillary Dilation Velocity;Retinal Detachment Range;Best Corrected Visual Acuity;	—

Secondary

Measure	Time frame
Sex;Age;Duration of RRD;Uncorrected visual acuity;Intraocular pressure;PVEP Peak Latency and Amplitude;FVEP Peak Latency and Amplitude;Diopter;	—

Countries

China

Contacts

Public ContactZijing Huang

Shantou University, Chinese University of Hong Kong united Shantou International Eye Center

huangzj@jsiec.org+86 138 2608 1137

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026