Obsessive-compulsive disorder
Conditions
Interventions
True stimulation group:5 consecutive days of continuous theta-burst stimulation (cTBS) targeting bilateral supplementary motor area (SMA) at 110% resting motor threshold (RMT), delivering 1,800 pulses
Sham stimulation group:The sham group received stimulation using a sham coil with parameters identical to the active group. During intervention, identical auditory cues were delivered, but the generat
Healthy group:Healthy participants are required to undergo baseline assessments and complete relevant data collection procedures following enrollment.
Sponsors
Nanjing Medical University Affiliated Nanjing Brain Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Obsessive-Compulsive Disorder (OCD) Patient Group a) Age 18-55 years; b) Meet DSM-5 diagnostic criteria for OCD (Yale-Brown Obsessive Compulsive Scale [Y-BOCS] severity score >=20); c) Stable conventional pharmacotherapy for at least 4 weeks prior to intervention or medication-naïve; d) No history of electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), or other neuromodulation treatments within the past 3 months; e) Sufficient educational and cultural background to comprehend the informed consent and study procedures; f) Voluntarily participate in the study and provide written informed consent. Healthy Control Group a) Age 18-55 years, matched to the patient group in sex, age, and other demographic factors; b) Screened negative via the Chinese version of the Mini-International Neuropsychiatric Interview (MINI); c) Sufficient educational and cultural background to comprehend the informed consent and study procedures; d) Voluntarily participate in the study and provide written informed consent.
Exclusion criteria
Exclusion criteria: Obsessive-Compulsive Disorder (OCD) Patient Group a) Contraindications to TMS (e.g., seizure risk, substance abuse, intracranial metallic implants, neurological disorders, or neurosurgical history); b) Comorbid psychiatric disorders (e.g., schizophrenia, bipolar disorder, major depressive disorder with psychotic features); c) Active suicidal ideation/behavior (Beck Depression Inventory-II [BDI-II] score >39) or self-harm risk; d) Pregnant or lactating women; e) Severe systemic medical conditions (e.g., decompensated cardiovascular, hepatic, or renal diseases). Healthy Control Group a) Contraindications to transcranial magnetic stimulation (TMS) (e.g., seizure risk, substance use disorders, metallic implants, history of neurological disorders or neurosurgery); b) Comorbid psychiatric disorders (e.g., schizophrenia, bipolar disorder, or substance dependence per DSM-5 criteria); c) Use of psychotropic medications or psychoactive substances (e.g., cannabis, stimulants) within the past 3 months; d) Severe suicidal/self-harm behaviors or elevated suicide attempt risk (Beck Depression Inventory-II [BDI-II] score >39); e) Pregnancy or lactation; f) Severe systemic medical conditions (e.g., unstable cardiovascular disorders, hepatic/renal insufficiency, or poorly controlled diabetes).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Yale-Brown scale for obsessive-compulsive symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Beck Anxiety Inventory;Beck Depression Inventory;obsessive-compulsive inventory-revised;University of S?o Paulo Sensory Phenomena Scale (USP-SPS); | — |
Countries
China
Contacts
Public ContactLiu Na
Nanjing Medical University Affiliated Nanjing Brain Hospital
Outcome results
None listed