Hyperuricemia
Conditions
Interventions
Placebo control group:The volunteers in this group were given dietary guidance, limiting the intake of high-purine foods such as animal organs, beer and sugary drinks, maintaining three regular meals
Low-dose Eucommia ulmoides leaf extract intervention group:The volunteers in this group were given dietary guidance, limiting the intake of high-purine foods such as animal organs, beer and sugary dri
High-dose Eucommia ulmoides leaf extract intervention group:The volunteers in this group were given dietary guidance, limiting the intake of high-purine foods such as animal organs, beer and sugary dr
Sponsors
College of Public Health, Medical College, Qingdao University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: According to the 2019 edition of the Chinese Guidelines for the Diagnosis and Treatment of Hyperuricemia and Gout, regardless of gender, if an adult's fasting blood uric acid level exceeds 420 µ mol/L on a daily diet, it can be diagnosed as hyperuricemia (HUA). 1. Meet the above diagnostic criteria for HUA in Western medicine, with 420 µ mol/L<SUA; 2. The patient is aged between 18 and 65 years old; 3. Have not taken any other traditional Chinese medicine in the past 6 months; 4. Failure to participate in clinical research, or cessation of drug elution for more than 6 months after participating in clinical research; 5. Voluntarily sign an informed consent form and cooperate with the treatment provider.
Exclusion criteria
Exclusion criteria: 1. Those who do not meet the above diagnostic criteria and inclusion criteria; 2. Secondary HUA caused by malignant tumor, kidney disease, diabetes or other diseases and treatment methods; 3. During the acute gouty arthritis attack period, there are symptoms of joint redness, swelling, heat, and pain; 4. Those who use drugs such as salicylates, furosemide, and thiazide that affect SUA metabolism; 5. Those who plan to undergo surgery in the near future; 6. Individuals with severe cardiovascular disease; 7. Patients with severe kidney damage (ClScr<30ml/min) and/or severe liver damage (Child Pugh C grade); 8. Use of psychoactive substances, drug abuse and dependence; 9. Individuals with a recent history of excessive drinking or alcoholism; 10. Individuals who have experienced allergies to the intervention components used in this study; 11. Those who have not taken the intervention according to regulations, cannot judge the efficacy, or have incomplete data that affects the efficacy or safety judgment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Uric acid, UA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fasting blood glucose, FBG;Total cholesterol, TC;Triglycerides, TG;Low-density lipoprotein, LDL;High-density lipoprotein, HDL;Body mass index, BMI ;CRP; | — |
Countries
China
Contacts
Public ContactHui Liang
College of Public Health, Medical College, Qingdao University
Outcome results
None listed