Pituitary tumor
Conditions
Interventions
Gold Standard:Clinical manifestations of typical Cushing syndrome + positive for any of the following screening tests: A. Two 24-hour urinary free cortisol (UFC) >= the upper limit of normal laborator
B. Overnight 1 mg dexamethasone inhibition test (1 mgDST), serum cortisol > 1.8 µg/dl (> 50 nmol/L)
C. Salivary cortisol > 145 µg/dl (> 4 nmol/L) twice late at night (23:00)
D. Classic low-dose dexamethasone inhibition test (LDDST), serum cortisol > 1.8 µg/dl (> 50 nmol/L
If the clinical manifestations are not typical, a diagnostic test is added: blood cortisol circadian rhythm or low-dose dexamethasone inhibition test + adrenocorticotropin release hormone (CRH) excita
Index test:Visual measurement of cortisol, plasma cortisol, urine cortisol
Sponsors
Yibin Second People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with Cushing's syndrome: With typical clinical manifestations of Cushing's syndrome + positive for any of the following screening tests: 1. Two 24-hour urinary free cortisol (UFC) >= the upper limit of the laboratory normal value; 2. Overnight 1 mg dexamethasone inhibition test (1 mgDST), serum cortisol > 1.8 µg/dl (> 50 nmol/L); 3. Salivary cortisol > 145 µg/dl (> 4 nmol/L) twice late at night (23:00); 4. Classic low-dose dexamethasone inhibition test (LDDST), serum cortisol > 1.8 µg/dl (> 50 nmol/L; If the clinical manifestations are not typical, a diagnostic test is added: blood cortisol circadian rhythm or low-dose dexamethasone inhibition test + adrenocorticotropin release hormone (CRH) excitation test (Dex-CRH). Healthy people: There was no obvious abnormality of liver and kidney function in our hospital; 2. Accept plasma cortisol testing.
Exclusion criteria
Exclusion criteria: Patients with Cushing's syndrome: 1.. accompanied by other tumors, cardiovascular and cerebrovascular diseases, autoimmune diseases; 2.. other metabolic diseases; 3.. Patients with incomplete case data or incomplete information for other reasons. Healthy people: 1. accompanied by other tumors, cardiovascular and cerebrovascular diseases, autoimmune diseases and other metabolic diseases; 2.. Patients with incomplete case data or incomplete information for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cortisol;Cut off value; | — |
Secondary
| Measure | Time frame |
|---|---|
| cortisol;Sensitivity;Specificity;Area under the curve; | — |
Countries
China
Contacts
Public ContactLin Qianli
Yibin Second People's Hospital
Outcome results
None listed