Early stage lung cancer
Conditions
Interventions
Experimental group (group B):Lung expansion with 100% CO2 in lung segmentectomy
Control group (group A):Lung expansion with 100% O2 in lung segmentectomy
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
20 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1. Age: 20~79 years old; 2. Preoperative CT shows tumor diameter =0.5; 3. Preoperative CT showed peripheral-type solitary nodule or concomitant lesion was microinfiltration and below; 4. Intraoperative frozen diagnostic margins were negative 5. Good lung function [actual one-second expiratory volume with exertion FEV1 >=1.5L or FEV1/exertion lung volume; >=60%], able to tolerate both segmental and lobectomy; 6. Eastern Cooperative Oncology Group (ECOG) physical status score of 0 to 2; 7. Voluntary participation and signed informed consent, ability to comply with the study modality plan and other protocol requirements
Exclusion criteria
Exclusion criteria: 1. Patients with emphysema; 2. Patients with preoperative imaging or mediastinal lymph node puncture suggesting positive preoperative lymph nodes; 3. Patients with distant metastasis or pleural fluid or ascites detected by preoperative examination; 4. Those who are diagnosed as carcinoma in situ, micro-invasive adenocarcinoma or papillary carcinoma by intraoperative freezing; 5. Those with severe impairment of heart, liver or kidney function; 6. Those with history of lung surgery or radiotherapy; 7. Extensive pleural adhesions; 8. Pregnant or breastfeeding women; 9. Pre-operative anti-tumor therapy by any means, including interventional chemoembolization, ablation, radiotherapy, chemotherapy, and molecular targeted therapy; 10. History of other malignant tumors within 5 years prior to enrollment; 11. Other uncontrollable and inoperable patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time of identifying the intersegmental plane;Oxygenation capacity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Operation duration;Blood loss during the operation;Postoperative length of hospitalisation;Thoracic drainage time after surgery; | — |
Countries
China
Contacts
Public ContactZhang Guangjian
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed