Intracranial space-occupying lesion
Conditions
Interventions
III:During the maintenance phase, a continuous infusion of cisatracurium at a rate of 0.1mg/(kg·h) was administered
I:During the maintenance phase, a continuous infusion of cisatracurium at a rate of 0.025 mg/(kg·h) was administered
II:During the maintenance phase, a continuous infusion of cisatracurium at a rate of 0.05mg/(kg·h) was administered
Sponsors
The First Affiliated Hospital, Jinan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients undergoing resection of intracranial space-occupying lesions with intraoperative somatosensory evoked potentials (SEP) and motor evoked potentials (MEP) monitoring; 2.Aged 18–65 years, with a body mass index (BMI) of 22–35 kg/m^2; 3.American Society of Anesthesiologists (ASA) physical status classification I–II; 4.No significant preoperative abnormalities in cardiac, pulmonary, hepatic, or renal function; 5.No obvious motor deficits in the limbs on physical examination, intact sensory conduction pathways, no median nerve injury, and no abnormalities in neuromuscular transmission.
Exclusion criteria
Exclusion criteria: 1.Patients with contraindications to neurophysiological monitoring, such as those with cochlear implants, cardiac pacemaker implants, a history of epilepsy, cranial bone defects, or infections at the monitoring site; 2.Patients with a known allergy to cisatracurium or any of its components; 3.Patients with a history of neuromuscular disease or those currently using medications that may interfere with neurophysiological monitoring; 4.Patients who refuse to participate in the study; 5.Pregnant women; 6.Patients who are likely to have a difficult airway; 7.Patients whose neurophysiological signals are extremely unstable due to non-patient factors such as equipment interference; 8.Other circumstances deemed by the investigator as unsuitable for inclusion in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Motor Evoked Potential;Somatosensory Evoked Potential; | — |
Secondary
| Measure | Time frame |
|---|---|
| Surgeon and Anesthesiologist Satisfaction; | — |
Countries
China
Contacts
Public ContactHu Donghua
The First Affiliated Hospital, Jinan University
Outcome results
None listed