Lung cancer
Conditions
Interventions
Nebulized pentethylquine hydrochloride group:After insertion of a single-lumen endotracheal tube, ultrasound nebulization of 0.5 mg of pentethylquine hydrochloride was performed, and then an occluder
Intravenous pentethylquine hydrochloride group:The single-lumen endotracheal tube was inserted intravenously with 0.5 mg of pentethylquine hydrochloride and then an occluder was inserted
Sponsors
Nanjing Meishan Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Patients who underwent elective left lobectomy, regardless of gender, age 18~64 years old, BMI 18~27.9 kg/m^2, ASA grade II or III
Exclusion criteria
Exclusion criteria: Glaucoma or other disorders with increased intraocular pressure; Patient's history of previous lung surgery; Severe arrhythmia, coronary heart disease, liver and kidney dysfunction; Presence of pulmonary diseases such as COPD (except GOLD1), asthma, lung infection, and bronchiectasis before surgery; History of radiotherapy-free treatment before surgery; Patient refuses to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lung dynamic compliance at 60 min of OLV; | — |
Secondary
| Measure | Time frame |
|---|---|
| Arterial partial pressure of oxygen;Peak airway pressure;Lung dynamic compliance at other time points;Incidence of hypoxemia;Arterial partial pressure of carbon dioxide;Platform press;Airway actuation pressure;Mean arterial pressure;Heart rate;Pulmonary infection score on postoperative day 2;Bilateral pulmonary complication rates during hospitalization and within 30 days after surgery;Occurrence of postoperative delirium;Cough and sputum production;Incidence of dry mouth and dry eyes;Number of days of postoperative hospital stay for patients;Time to extubation;Exhaust time; | — |
Countries
China
Contacts
Public ContactWang Qiang
Nanjing Meishan Hospital
Outcome results
None listed