Effects of lidocaine on cerebral oxygen metabolism and perioperative neurocognitive disorders in patients with single lung ventilation

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500102315

Enrollment

Unknown

Registered

2025-05-13

Start date

2023-01-07

Completion date

Unknown

Last updated

2025-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative cognitive dysfunction

Interventions

control group:The control group was given the same dose of saline as the intervention group.

lidocaine group:A single intravenous infusion of lidocaine at a dose of 1.5 mg/kg was administered for > 5 s at induction of anesthesia, followed by continuous intravenous infusion of lidocaine at 1.5

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Patients undergoing thoracoscopic lobectomy or segmental resection under general anesthesia. 2.BMI 18-25 kg/m^2. 3.ASA I or II level.

Exclusion criteria

Exclusion criteria: 1. Lidocaine allergy. 2. Chronic alcoholism 3. Culture below junior high school. 3. Cardiovascular and cerebrovascular diseases, abnormal liver and kidney function. 4. Hypertension, diabetes, anemia. 5. Lung function examination FEV1/FVC< 65%. 6. Long-term use of sedative and analgesic drugs, coagulation dysfunction. 7. Intraoperative blood loss of more than 300 ml.

Design outcomes

Primary

Measure	Time frame
cerebral oxygen metabolism;	—

Countries

China

Contacts

Public ContactWang Yong

Yixing Hospital of Traditional Chinese Medicine

wywwb305@163.com+86 159 6159 8637

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026