Elderly patients undergoing thoracoscopic lung surgery
Conditions
Interventions
Group P:Anesthesia induction and maintenance were performed using propofol-based total intravenous anesthesia
Group R:Anesthesia induction and maintenance were performed using remimazolam-based total intravenous anesthesia (TIVA)
Group C:Anesthesia induction and maintenance were performed using ciprofol-based total intravenous anesthesia (TIVA)
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=65 years; 2. American Society of Anesthesiologists (ASA) Physical Status Classification: I-III; 3. Scheduled for elective thoracoscopic wedge resection, segmentectomy, or lobectomy; 4. Expected duration of surgery >=1.5 hours.
Exclusion criteria
Exclusion criteria: 1. Scheduled for elective thoracoscopic pneumonectomy; 2. Known contraindications to benzodiazepines, opioids, muscle relaxants, or investigational drugs; 3. History of psychiatric disorders, long-term use of psychotropic medications, or cognitive dysfunction; 4. History of alcohol abuse or substance misuse within the past two years; 5. Postoperative transfer to ICU with endotracheal intubation; 6. Currently enrolled in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 score on postoperative day 1 (POD 1); | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative hypotension;Emergence time;PACU delirium;PACU hypoxemia;Postoperative pain on POD 1, 2, and 3;Postoperative nausea and vomiting (PONV);QoR-15 scores on POD 2 and 3;Sleep quality assessed by Pittsburgh Sleep Quality Index (PSQI);Total perioperative analgesic consumption;Days at Home up to 30 Days after Surgery;30-day all-cause mortality; | — |
Countries
China
Contacts
Public ContactYu Hai
West China Hospital, Sichuan University
Outcome results
None listed