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To investigate the minimum dose of respiratory depression induced by afentanil analgesia based on improved Dixon sequential method

To investigate the minimum dose of respiratory depression induced by afentanil analgesia based on improved Dixon sequential method

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500102289
Enrollment
Unknown
Registered
2025-05-13
Start date
2025-07-01
Completion date
Unknown
Last updated
2025-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thyroid tumor

Interventions

Experimental group:The patient was given 100ug/ml of afentanil injection 5-10min after entry. The dose of afentanil received by subsequent enrollees depends on whether respiratory depression occurred

Sponsors

First Affiliated Hospital of Shihezi University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. General anesthesia patients who are planning to undergo surgery; 2. Patients aged between 18 and 65 years old; 3.BMI<28.

Exclusion criteria

Exclusion criteria: 1. Patients with cardiovascular and pulmonary diseases that affect respiration and oxygenation (or patients with preoperative respiratory distress and decreased blood oxygen saturation); 2. Preoperative evaluation of patients with difficult airways; 3. Patients with preoperative coexisting pain; 4. Patients with unstable preoperative vital signs; 5. The patient is allergic to opioid drugs; 6. The patient refuses to accept.

Design outcomes

Primary

MeasureTime frame
Pulse oxygen saturation;

Secondary

MeasureTime frame
Respiratory rate;Apnea time;

Countries

China

Contacts

Public ContactCai Xiaobin

First Affiliated Hospital of Shihezi University

56533686@qq.com+86 131 3993 7558

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026