Lung cancer
Conditions
Interventions
Esketamine + continuous block group (ESK+ continuous block group):During anesthesia induction, 0.25 mg/kg esketamine injection was intravenously injected. After anesthesia induction, ultrasound-guided
Esketamine + Single block group (ESK+ Single block group):During anesthesia induction, 0.25 mg/kg esketamine injection was intravenously injected. After anesthesia induction, ultrasound-guided erector
The infusion rate is 2 mL/h.
Normal saline + continuous block group (NS+ continuous block group):During anesthesia induction, an equal volume of normal saline was intravenously injected. After anesthesia induction, ultrasound-gui
Sponsors
The First Affiliated Hospital of Bengbu Medical College
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age 65-80 years old, American Society of Anesthesiologists (ASA) grade II or III, NYHA grade I-III of cardiac function, and meeting three or more criteria in the FRAIL Frailty Assessment Scale; 2.It is planned to perform radical resection of lung cancer under thoracoscopy under general anesthesia. After assessment; 3.It can tolerate general anesthesia. 4.Preoperative bronchoscopy or puncture pathological examination results confirmed lung cancer or highly suspected lung cancer patients; 5.Sign the informed consent form for the research.
Exclusion criteria
Exclusion criteria: 1.Have mental system diseases or take antipsychotic drugs before the operation; 2.Allergic to or contraindicated to anesthetic drugs such as esketamine; 3.There are contraindications for erector spinae plane block; 4.Severe cardiac insufficiency (NYHA grade IV), abnormal liver function (Child-Pugh grade C, Annex 1), severe abnormal renal function (preoperative dialysis) or ASA grade >= grade IV; 5.Situations where other researchers or attending physicians consider it inappropriate to participate in the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression score (HAMD-17 Scale) 7 days after the operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| The depression (HAMD-17) score 30 days after the operation;The anxiety (GAD-7) scores at 7 and 30 days after the operation;The pain during rest/cough (NRS) scores at 24 and 48 hours after the operation; | — |
Countries
China
Contacts
Public ContactCongli Zhang
The First Affiliated Hospital of Bengbu Medical College
Outcome results
None listed